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Pharmacology: Pharmacodynamics: Lysozyme is an enzyme having a mucopolysaccharide lysing action. It enhances the effect of antibiotics to destroy or weaken cell bacteria.
Lysozyme also accelerates immuno-bacteriolysis and activates the phagocytosis activity of leukocytes to destroy bacteria and viruses.
Lysozyme is widely distributed in tears, nasal discharge, saliva and also breast milk.
Lysozyme extracted from egg-white is used clinically for the intensification of natural defense mechanisms, restoration of damaged tissue and anti-inflammation.
The body needs pyridoxine hydrochloride in order to make cells of the immune system. Pyridoxine hydrochloride helps to improve immune response to the increase in production of antibodies and also helps in communicative interactions between cytokines and chemokines.
Pharmacokinetics: With a single 900mg (potency) oral dose of lysozyme chloride, the peak plasma concentration occurred about 30 minutes to 1 hour after administration.
Pyridoxine hydrochloride is absorbed rapidly from the upper intestine regardless of the size of the dose given.
Absorption may also occur from the ileum and to a small extent from the colon. These observations suggest the possibility that pyridoxine may be absorbed by diffusion.
Pyridoxine is rapidly converted in the liver to pyridoxine phosphate, pyridoxal phosphate and pyridoxamine phosphate via oxidation, this causes the release of pyridoxal and so pyridoxal phosphate to the general circulation where it reaches other organs chiefly as circulating pyridoxal.
In urine, pyridoxine was excreted primarily unchanged with a small amount of only one metabolite, most likely 4-pyridoxic acid.
Oral liquid: Absorption and Distribution: following administration of [1]-labelled egg white lysozyme (2mg/kg) into the intestinal tract of rats, peak serum and lymphatic concentration occurred at 30 minutes.
